Maria M M Santos Selected Research

tryptophanol

3/2021	Tryptophanol-Derived Oxazolopyrrolidone Lactams as Potential Anticancer Agents against Gastric Adenocarcinoma.
1/2021	Potency and Selectivity Optimization of Tryptophanol-Derived Oxazoloisoindolinones: Novel p53 Activators in Human Colorectal Cancer.
1/2020	SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner.
8/2019	SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma.
10/2018	Improving anticancer activity towards colon cancer cells with a new p53-activating agent.
5/2015	A tryptophanol-derived oxazolopiperidone lactam is cytotoxic against tumors via inhibition of p53 interaction with murine double minute proteins.

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Maria M M Santos Research Topics

Disease

13	Neoplasms (Cancer) 03/2021 - 05/2014
4	Colonic Neoplasms (Colon Cancer) 01/2021 - 01/2017
3	Malaria 06/2022 - 12/2015
2	Colorectal Neoplasms (Colorectal Cancer) 01/2021 - 01/2019
2	Neurodegenerative Diseases (Neurodegenerative Disease) 08/2016 - 01/2015
1	Parasitic Diseases (Parasitic Disease) 01/2022
1	Trypanosomiasis 01/2022
1	Leishmaniasis 01/2022
1	Carcinogenesis 01/2022
1	Inflammation (Inflammations) 01/2022
1	Melanoma (Melanoma, Malignant) 04/2021
1	Adenocarcinoma 03/2021
1	Ovarian Neoplasms (Ovarian Cancer) 01/2021
1	Nervous System Diseases (Neurological Disorders) 05/2020
1	Hepatocellular Carcinoma (Hepatoma) 08/2019
1	Glioma (Gliomas) 01/2019
1	Brain Neoplasms (Brain Tumor) 01/2019
1	Triple Negative Breast Neoplasms 11/2017
1	Alzheimer Disease (Alzheimer's Disease) 01/2017
1	Parkinson Disease (Parkinson's Disease) 08/2016
1	Breast Neoplasms (Breast Cancer) 05/2014
1	Dehydration (Water Stress) 02/2009

Drug/Important Bio-Agent (IBA)

6	OxindolesIBA 06/2022 - 05/2014
6	tryptophanolIBA 03/2021 - 05/2015
5	Proteins (Proteins, Gene)FDA Link 04/2021 - 01/2015
4	LactamsIBA 03/2021 - 05/2015
3	SLMP53-2IBA 01/2022 - 08/2019
3	Tumor Suppressor Protein p53IBA 03/2021 - 05/2015
3	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 05/2020 - 08/2016
2	Lactic Acid (Lactate)FDA LinkGeneric 04/2021 - 01/2020
2	Antineoplastic Agents (Antineoplastics)IBA 03/2021 - 08/2019
2	2-oxindole (oxindole)IBA 01/2019 - 10/2017
1	indoleIBA 01/2022
1	Pharmaceutical PreparationsIBA 01/2022
1	DNA (Deoxyribonucleic Acid)IBA 01/2022
1	Polycyclic CompoundsIBA 03/2021
1	Biological ProductsIBA 01/2021
1	Cadherins (E-Cadherin)IBA 01/2020
1	Glucose (Dextrose)FDA LinkGeneric 01/2020
1	SpirooxindolesIBA 01/2019
1	Doxorubicin (Adriamycin)FDA LinkGeneric 10/2018
1	Fluorouracil (Carac)FDA LinkGeneric 10/2017
1	Transcription Factors (Transcription Factor)IBA 01/2017
1	DIMP53-1IBA 01/2017
1	Memantine (Namenda)FDA Link 01/2017
1	Amantadine (Aman)FDA LinkGeneric 08/2016
1	QuinolizidinesIBA 08/2016
1	Chloroquine (Aralen)FDA LinkGeneric 12/2015
1	AlkaloidsIBA 01/2015
1	Estrogen ReceptorsIBA 05/2014
1	human ERBB2 proteinIBA 05/2014
1	OximesIBA 02/2009
1	AldehydesIBA 02/2009

Therapy/Procedure

5	Therapeutics 04/2021 - 01/2017
2	Drug Therapy (Chemotherapy) 01/2019 - 10/2018